Benicio Del Toro stars as Lawrence Talbot, a gentleman tormented by the death of his mother and subsequent end of his childhood, who leaves home to try and rid himself of the memories and hurt. However, years later he is contacted by his brother's fiancee, Gwen Conliffe, who tells of how her love has gone missing, leading Talbot to return home in order to help with the search. Upon his arrival, however, he discovers that something horrifyingly strong with a seemingly unquenchable thirst for blood has been terrorising the villagers. With the death toll rising, a very suspicious Inspector Aberline from Scotland Yard is on the case. As he begins to uncover the truth, he hears about a curse that transforms the affected into a werewolf under the full moon...